Human three-dimensional engineered muscle tissue characterization and intramyocellular lipid modeling

Originally Published in: Journal of Tissue Engineering (September 2025) (Download the Publication)

Mantarray, Media, Curi Bio CellsArianna KieserSeptember 15, 2025

Activin receptor type IIA/B blockade increases muscle mass and strength, but compromises glycemic control in mice

Originally Published in: bioRxiv (June 2025) (Link to Original Posting)

Mantarray, MediaArianna KieserJuly 21, 2025

AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models

Originally Published in: Nature Communications (February 2025) (Link to Original Posting)

Mantarray, NautilaiArianna KieserMarch 4, 2025

ROR2 drives right ventricular heart failure via disruption of proteostasis

Originally Published in: bioRxiv (December 2025) [Download the Publication]

NanoSurface PlatesArianna KieserFebruary 2, 2025

Near Infrared-Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model

Originally Published in: Advanced Science (January 2025) [Read the Publication]

Mantarray, Mantarray PlatesArianna KieserJanuary 31, 2025

An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing

Originally Published in: Science Direct (January 2025) (Link to Original Posting)

MantarrayArianna KieserJanuary 31, 2025

Plakophilin-2 Coordinates Energy Metabolism and Contractility in Cardiomyocytes, Revealing Its Roles beyond Desmosomes

Originally Published in: bioRxiv (January 2025) (Link to Original Posting)

MantarrayArianna KieserJanuary 20, 2025

Modeling Genetic Dilated Cardiomyopathies with Engineered Heart Tissues From Patient-Derived and Isogenic Mutant Induced Pluripotent Stem Cells

Data from Tenaya Therapeutics (2022)

MantarrayArianna KieserAugust 9, 2024

Utility of a 3D–Engineered Skeletal Muscle Organoid System to Assess Exon Skipping, Dystrophin Protein Restoration, and Functional Improvement in a Human DMD Cell Model

Data from Entrada Therapeutics (2024)

MantarrayArianna KieserJuly 17, 2024

AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy

Originally Published in: Nature (March 2024) (Link to Paper)

AI/ML Data AnalyticsArianna KieserMarch 18, 2024

Combinatorial extracellular matrix cues with mechanical strain induce differential effects on myogenesis in vitro

Originally Published in: Biomaterials Science (2023) (Link to Paper)

Arianna KieserJuly 21, 2023Skeletal Muscle Cells

Preclinical Drug Testing in Scalable 3D Engineered Muscle Tissues

Originally Published in: JoVE Journal (2023) (Link to Paper)

MantarrayArianna KieserApril 7, 2023

Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes

Originally Published in: eLife (2021) (Link to Paper)

AI/ML Data AnalyticsArianna KieserJune 15, 2022Cardiomyocytes

High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing

Originally Published in: Sage Journals (2022) (Link to Paper)

MantarrayArianna KieserJune 15, 2022Skeletal Muscle Cells

Human perinatal stem cell derived extracellular matrix enables rapid maturation of hiPSC-CM structural and functional phenotypes

Originally Published in: Nature Scientific Reports (2022) (Link to Paper)

NautilaiArianna KieserJune 15, 2022Cardiomyocytes

Passive-Stretch Induced Skeletal Muscle Injury Platform for Duchenne Muscular Dystrophy Modeling

Originally Published in: Archives of Physical Medicine and Rehabilitation - V103, Issue 3 (2022) (Link to Paper)

Arianna KieserMarch 1, 2022Skeletal Muscle Cells

Using hiPSC-CMs to Examine Mechanisms of Catecholarminergic Polymorphic Ventricular Tachycardia

Originally Published in: Current Protocols (2021) (Link to Paper)

NanoSurface PlatesArianna KieserDecember 27, 2021CPVT Phenotype hiPSC Model

Combining stretching and gallic acid to decrease inflammation indices and promote extracellular matrix production in osteoarthritic human articular chondrocytes

Originally Published in: Experimental Cell Research - V408, Issue 2 (2021) (Link to Paper)

Arianna KieserNovember 15, 2021Osteoarthritic Human Articular Chondrocytes (hAChs)

BRAF Modulates Stretch-Induced Intercellular Gap Formation through Localized Actin Reorganization

Originally Published in: International Journal of Molecular Sciences (2021) (Link to Paper)

Arianna KieserAugust 17, 2021Human Endothelial Cells

Enhanced Matrix Production by Cocultivated Human Stem Cells and Chondrocytes Under Concurrent Mechanical Strain

Originally Published in: In Vitro Cellular & Developmental Biology - Animal (2021) (Link to Paper)

Arianna KieserJune 30, 2021Stem Cells

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