Neuromuscular Junction Model

3D Human Neuromuscular Junction Model

Curi Bio’s scalable, functional and quantifiable 3D human NMJ model is a high-throughput, iPSC-derived platform delivering unparalleled reproducibility for neurotoxin testing, drug discovery, and disease modeling.

DM1 Skeletal Muscle Myoblasts

Powering Translational Research with Patient Specific Human Myoblasts and CRISPR Corrected Isogenic Control

Skeletal Muscle Models

Curi Bio's 3D Engineered Muscle Tissues (EMTs) enable in vitro models of skeletal muscle contractility and Curi Bio’s 2D skeletal muscle model utilizes microtissues built by structurally maturing human skeletal muscle cells.

Cardiac Models

Curi Bio’s 3D Engineered Heart Tissues (EHTs) enable in vitro models of cardiac muscle contractility while our 2D heart model utilizes microtissues built by structurally maturing human iPSC-derived cardiomyocytes.

Curi Bio has licensed and/or developed advanced human tissue models for a number of monogenic disorders, including Duchenne Muscular Dystrophy (DMD) (see our DMD case study). Additional models include:

• Myotonic Dystrophy Type 1 (DM1)

• Facioscapulohumeral Muscular Dystrophy (FSHD)

• X-linked Myotubular Myopathy (XLMTM)

• Hypertrophic & Dilated Cardiomyopathies (HCM/DCM)

• and More

Contact our team to discover how Curi Bio can help accelerate your disease research and therapeutic discoveries by providing access to our pre-made disease model library, tissue models, and tissue-specific biosystems. Curi Bio is actively pursuing additional partnerships to create new disease models.

Skeletal Muscle Metabolic Media

Physiologically Formulated to Drive Translational Metabolic Discovery

• Reproducible Results

• Physiological Relevance

• Serum-Free Formulation

• Designed for Metabolic Assays

3D Skeletal Muscle Tissue Media

Curi Bio's proprietary serum-free medium provides longer culture times and stronger contractile force.

Advance Your 3D Skeletal Muscle Tissue Experiments

• Stronger Tissues

• Faster Kinetics

• Greater Longevity

iPSC-Derived Skeletal Muscle Myoblasts

Ready to Cast Isogenic Control and Duchenne Muscular Dystrophy Human Myoblasts for 3D Engineered Muscle Tissue Experiments

Enable discovery and validation of new therapeutics with Curi Bio's high fidelity DMD tissue model.

3D Cardiac Muscle Tissue Media

Promote mature cardiac phenotypes over months in culture with Curi Bio’s next-generation cell culture media for 3D cardiac models.

Generate Human Relevant Functional Cardiac Data

• Physiological Metabolism

• Stronger Tissues

• Improved Kinetics

Isogenic MYBPC3 Hypertrophic Cardiomyopathy Model

Cryopreserved, Assay-Ready Cardiomyocytes for Advanced Cardiac Disease Research

With the MYBPC3e6 Isogenic Pair, you gain:

• Genetic Fidelity

• Physiological Relevance

• Translational Power