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Platforms Overview Biosystem Platforms Mantarray™ – 3D Tissue Contractility Analysis Mantarray Mini Plates – Fewer Cells. More Data. Nautilai™ – Voltage & Calcium Imaging Stingray™ – Maturation of 3D Engineered Tissues NanoSurface™ Plates – HCI Plates for Structural Maturation Data Analytics Platforms Pulse™ – High-Throughput Video Contractility Analysis Software
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Mantarray™

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Functionally Mature Bioengineered Human Skeletal Muscle Tissues Capture Essential Aspects of Glucose Metabolism
Mantarray, Media
Functionally Mature Bioengineered Human Skeletal Muscle Tissues Capture Essential Aspects of Glucose Metabolism
Mantarray, Media

Originally Published in: BioRxiv (January 2026) (Download the Preprint)

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Mantarray, Media
Maintenance of Energy Metabolism Is an Integral Part of Plakophilin-2 and Desmosome Functions
Mantarray, Nautilai, AI/ML Data Analytics
Maintenance of Energy Metabolism Is an Integral Part of Plakophilin-2 and Desmosome Functions
Mantarray, Nautilai, AI/ML Data Analytics

Originally Published in: JACC: Basic to Translational Science (December 2025) (Download the Publication)

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Mantarray, Nautilai, AI/ML Data Analytics
Reduced Expression of MTSS1 Increases Sarcomere Number and Improves Contractility in Select Forms of Monogenic DCM
Mantarray
Reduced Expression of MTSS1 Increases Sarcomere Number and Improves Contractility in Select Forms of Monogenic DCM
Mantarray

Originally Published in: JACC: Basic to Translational Science (October 2025) (Download)

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Mantarray
Human three-dimensional engineered muscle tissue characterization and intramyocellular lipid modeling
Mantarray, Media, Curi Bio Cells
Human three-dimensional engineered muscle tissue characterization and intramyocellular lipid modeling
Mantarray, Media, Curi Bio Cells

Originally Published in: Journal of Tissue Engineering (September 2025) (Download the Publication)

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Mantarray, Media, Curi Bio Cells
SYNPO2L Isoforms Regulate the Action Potential Characteristics and Contractility of Atrial Cardiomyocytes via YAP Signaling to Modulate Atrial Fibrillation Risk
Mantarray, Mantarray Plates, Nautilai
SYNPO2L Isoforms Regulate the Action Potential Characteristics and Contractility of Atrial Cardiomyocytes via YAP Signaling to Modulate Atrial Fibrillation Risk
Mantarray, Mantarray Plates, Nautilai

Originally Published in: bioRvix (August 2025) [Link to Full Publication]

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Mantarray, Mantarray Plates, Nautilai
Activin receptor type IIA/B blockade increases muscle mass and strength, but compromises glycemic control in mice
Mantarray, Media
Activin receptor type IIA/B blockade increases muscle mass and strength, but compromises glycemic control in mice
Mantarray, Media

Originally Published in: bioRxiv (June 2025) (Link to Original Posting)

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Mantarray, Media
AI-guided laser purification of human iPSC-derived cardiomyocytes for next-generation cardiac cell manufacturing
Mantarray, Mantarray Plates
AI-guided laser purification of human iPSC-derived cardiomyocytes for next-generation cardiac cell manufacturing
Mantarray, Mantarray Plates

Originally Published in: Communications Biology (May 2025) [Link to Full Publication]

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Mantarray, Mantarray Plates
AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models
Mantarray, Nautilai
AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models
Mantarray, Nautilai

Originally Published in: Nature Communications (February 2025) (Link to Original Posting)

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Mantarray, Nautilai
Near Infrared-Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model
Mantarray, Mantarray Plates
Near Infrared-Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model
Mantarray, Mantarray Plates

Originally Published in: Advanced Science (January 2025) [Read the Publication]

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Mantarray, Mantarray Plates
An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing
Mantarray
An automated platform for simultaneous, longitudinal analysis of engineered neuromuscular tissues for applications in neurotoxin potency testing
Mantarray

Originally Published in: Science Direct (January 2025) (Link to Original Posting)

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Mantarray
Preclinical Drug Testing in Scalable 3D Engineered Muscle Tissues
Mantarray
Preclinical Drug Testing in Scalable 3D Engineered Muscle Tissues
Mantarray

Originally Published in: JoVE Journal (2023) (Link to Paper)

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Mantarray
High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing
Mantarray
High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing
Mantarray

Originally Published in: Sage Journals (2022) (Link to Paper)

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Mantarray
 

Nautilai™ Publications

 

Data Analytics Platforms Publications

Featured
Maintenance of Energy Metabolism Is an Integral Part of Plakophilin-2 and Desmosome Functions
Maintenance of Energy Metabolism Is an Integral Part of Plakophilin-2 and Desmosome Functions

Originally Published in: JACC: Basic to Translational Science (December 2025) (Download the Publication)

Read More →
AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy
AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy

Originally Published in: Communications Medicine (March 2024) (Link to Paper)

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Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes
Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes

Originally Published in: eLife (2021) (Link to Paper)

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Featured

NanoSurface Plate Publications

Featured
ROR2 drives right ventricular heart failure via disruption of proteostasis
ROR2 drives right ventricular heart failure via disruption of proteostasis

Originally Published in: bioRxiv (December 2025) [Download the Publication]

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A Live Cell Reporter of Exosome Secretion and Uptake Reveals Pathfinding Behavior of Migrating Cells
A Live Cell Reporter of Exosome Secretion and Uptake Reveals Pathfinding Behavior of Migrating Cells

Originally Published in: Nature Communications (2020) (Link to Paper)

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Switch-like Enhancement of Epithelial-mesenchymal Transition by YAP Through Feedback Regulation of WT1 and Rho-family GTPases
Switch-like Enhancement of Epithelial-mesenchymal Transition by YAP Through Feedback Regulation of WT1 and Rho-family GTPases

Originally Published in: Nature Communications (2019) (Link to Paper)

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