Measure BoNT potency in a 3D human neuromuscular junction model with reproducible dose-response curves, a human, animal-free alternative to the mouse lethality bioassay.
Develop disease models or screen compounds in cardiac and skeletal muscle tissues at 96-well scale. Nautilai Plus™ measures contractility and fluorescence across every well for high-throughput drug discovery.
Model decades of disease progression in weeks with 3D heart tissues on Mantarray™. Our MYBPC3 fibrotic EHTs show impaired relaxation kinetics and hallmarks of fibrosis to screen antifibrotic therapies.
Our iPSC-derived 3D engineered skeletal muscle tissues report contractile force in real time to characterize functional atrophy phenotypes relevant to sarcopenia and screen candidate therapies.
Curi Bio’s Metabolic Media boosts insulin sensitivity and force in Cook MyoSite 3D muscle models. Measure glucose uptake and metabolites to characterize metabolic function and test candidate therapies.
Induce arrhythmic phenotypes in 3D EHTs with siRNA-mediated knockdown of PKP2. Mantarray measures twitch force and period, generating functional data to evaluate candidate antiarrhythmic therapies.
Run longitudinal cardiotoxicity studies in 3D heart tissues. Mantarray and Nautilai Plus capture delayed and cumulative liabilities missed by 2D and animal models to de-risk compounds.
Screen AAV capsids, LNPs, oligonucleotides, and gene editing in 3D muscle and heart tissues. Track payload delivery and contractility at 24- or 96-well scale to optimize and de-risk therapies.
Access disease-relevant iPSC lines via Greenstone Biosciences. Together, we built a 3D heart model of BAG3 dilated cardiomyopathy to profile phenotypes and drug responses on Mantarray.
Record calcium transients and action potentials in iPSC-cardiomyocyte monolayers. Nautilai measures AP duration, beat rate, and arrhythmia across plate formats to assess proarrhythmic risk.
Record calcium transients in 28bio CNS-3D Brain Organoids to evaluate network function. Nautilai quantifies frequency across plate formats to profile neuromodulatory compounds.