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Platforms Overview Biosystem Platforms Mantarray™ – 3D Tissue Contractility Analysis Mantarray Mini Plates – Fewer Cells. More Data. Nautilai™ – Voltage & Calcium Imaging Stingray™ – Maturation of 3D Engineered Tissues NanoSurface™ Plates – HCI Plates for Structural Maturation Data Analytics Platforms Pulse™ – High-Throughput Video Contractility Analysis Software
Models Overview Applications Neuromuscular Junction Model Skeletal Muscle Models Cardiac Models Disease Models Cells & Media 3D Skeletal Muscle Tissue Media Skeletal Muscle Myoblasts 3D Cardiac Media MYBPC3 HCM Cardiomyocytes Celogics Celo.Cardiomyocytes
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PLATFORMS Platforms Overview Biosystem Platforms Mantarray™ – 3D Tissue Contractility Analysis Mantarray Mini Plates – Fewer Cells. More Data. Nautilai™ – Voltage & Calcium Imaging Stingray™ – Maturation of 3D Engineered Tissues NanoSurface™ Plates – HCI Plates for Structural Maturation Data Analytics Platforms Pulse™ – High-Throughput Video Contractility Analysis Software MODELS Models Overview Applications Neuromuscular Junction Model Skeletal Muscle Models Cardiac Models Disease Models Cells & Media 3D Skeletal Muscle Tissue Media Skeletal Muscle Myoblasts 3D Cardiac Media MYBPC3 HCM Cardiomyocytes Celogics Celo.Cardiomyocytes SERVICES Curi Engine Services Curi Engine™ Services RESOURCES Publications & Poster Publications & Posters Product Literature Application Notes Webinars Videos Knowledge Base ABOUT Company Company News Events – Workshop World Tour Distributors Careers
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Peer-Reviewed Publications

 
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Microtubules orchestrate local translation to enable cardiac growth

Originally Published in: Nature Communications (2021) (Link to Paper)

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NanoSurface PlatesArianna KieserMarch 11, 2021Neonatal Rat Ventricular Myocytes (NRVMs)
Regional Differences and Physiologic Behaviors in Peripapillary Scleral Fibroblasts
Regional Differences and Physiologic Behaviors in Peripapillary Scleral Fibroblasts

Originally Published in: Investigative Ophthalmology and Visual Science (2021)

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Arianna KieserFebruary 8, 2021
Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals
Infarct Collagen Topography Regulates Fibroblast Fate via p38-Yes-Associated Protein Transcriptional Enhanced Associate Domain Signals

Originally Published in: Circulation Research, October 2020 (Link to Paper)

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NanoSurface PlatesArianna KieserSeptember 4, 2020Cardiac Tissue
A Live Cell Reporter of Exosome Secretion and Uptake Reveals Pathfinding Behavior of Migrating Cells
A Live Cell Reporter of Exosome Secretion and Uptake Reveals Pathfinding Behavior of Migrating Cells

Originally Published in: Nature Communications (2020) (Link to Paper)

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NanoSurface PlatesArianna KieserAugust 24, 2020
Cellular Locomotion Using Environmental Topography

Source: Reversat, A., Gaertner, F., Merrin, J. et al. Cellular locomotion using environmental topography. Nature582, 582–585 (2020). (Link to Paper)

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NanoSurface PlatesArianna KieserMay 13, 2020T Cells
Mechanical Tension in Syndecan-1 is Regulated by Extracellular Mechanical Cues and Fluidic Shear Stress

Source: (Link to Paper)

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NanoSurface PlatesArianna KieserMay 9, 2020Human Endothelial Cells
A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte
A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte

Source: Heffler J, Shah PP, Robison P, et al. A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte. Circ Res. 126(3):e10–e26, Publication Date: 2020 (Link to Paper)

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NanoSurface PlatesArianna KieserApril 28, 2020
Nanopatterned Nafion Microelectrode Arrays for In Vitro Cardiac Electrophysiology

Source: (Link to Paper)

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NanoSurface PlatesArianna KieserApril 22, 2020Cardiac Tissue
Dasatinib Inhibits Peripapillary Scleral Myofibroblast Differentiation

Originally Published in: Experimental Eye Research (2020) (Link to Paper)

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Arianna KieserMarch 13, 2020Eye Tissue
Engineering Anisotropic 3D Tubular Tissues with Flexible Thermoresponsive Nanofabricated Substrates

(Link to Paper)

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NanoSurface PlatesArianna KieserFebruary 14, 2020Human Endothelial Cells, Cardiac Tissue, Skeletal Muscle Cells
Switch-like Enhancement of Epithelial-mesenchymal Transition by YAP Through Feedback Regulation of WT1 and Rho-family GTPases
Switch-like Enhancement of Epithelial-mesenchymal Transition by YAP Through Feedback Regulation of WT1 and Rho-family GTPases

Originally Published in: Nature Communications (2019) (Link to Paper)

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NanoSurface PlatesArianna KieserFebruary 10, 2020
NanoMEA: A Tool for High-Throughput, Electrophysiological Phenotyping of Patterned Excitable Cells
NanoMEA: A Tool for High-Throughput, Electrophysiological Phenotyping of Patterned Excitable Cells

Alec S. T. Smith, Eunpyo Choi, Kevin Gray, Jesse Macadangdang, Eun Hyun Ahn, Elisa C. Clark, Michael A. Laflamme, Joseph C. Wu, Charles E. Murry, Leslie Tung, Deok-Ho Kim* Nano Lett. 2020, vol. 20, no. 3, pp. 1561-1570, Publication Date: December 17, 2019 (Link to Paper)

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NanoSurface PlatesArianna KieserFebruary 10, 2020
Evolution of Placental Invasion and Cancer Metastasis are Causally Linked

Kshitiz, Afzal, J., Maziarz, J.D. et al. Nat Ecol Evol 3, pp. 1743–1753, Publication Date: 2019 (Link to Paper)

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NanoSurface PlatesArianna KieserJanuary 17, 2020Melanoma Cancer Cells
Superresolution Architecture of Cornerstone Focal Adhesions in Human Pluripotent Stem Cells
Superresolution Architecture of Cornerstone Focal Adhesions in Human Pluripotent Stem Cells

Originally Published in: Nature Communications (2019) (Link to Paper)

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NanoSurface PlatesArianna KieserOctober 18, 2019Human Pluripotent Stem Cells
Matrix Topography Regulates Synaptic Transmission at the Neuromuscular Junction
Matrix Topography Regulates Synaptic Transmission at the Neuromuscular Junction

Originally Published in: Advanced Science (2019) (Link to Paper)

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NanoSurface PlatesArianna KieserMarch 20, 2019Skeletal Muscle Cells, Neuromuscular Junctions, Neurons
pHluo_M153R-CD63, a Bright, Versatile Live Cell Reporter of Exosome Secretion and Uptake, Reveals Pathfinding Behavior of Migrating Cells

Bong Hwan Sung, Roxanne Pelletier, Alissa M. Weaver, bioRxiv 577346, Publication Date: 2019 (Link to Paper)

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NanoSurface PlatesArianna KieserMarch 14, 2019
Microtubule-Actomyosin Mechanical Cooperation During Contact Guidance Sensing
Microtubule-Actomyosin Mechanical Cooperation During Contact Guidance Sensing

Originally Published in: Cell Reports (2018) (Link to Paper)

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NanoSurface PlatesArianna KieserOctober 9, 2018Human Breast Cancer Cells
Biomechanical Interplay Between Anisotropic Re-organization of Cells and the Surrounding Matrix Underlies Transition to Invasive Cancer Spread
Biomechanical Interplay Between Anisotropic Re-organization of Cells and the Surrounding Matrix Underlies Transition to Invasive Cancer Spread

Kim, D., Ewald, A.J., Park, J. et al. Sci Rep 8, 14210, Publication Date: 2018 (Link to Paper)

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NanoSurface PlatesArianna KieserSeptember 21, 2018Melanoma
Conductive Silk–polypyrrole Composite Scaffolds with Bioinspired Nanotopographic Cues for Cardiac Tissue Engineering

Jonathan H. Tsui et al. J. Mater. Chem. B, 6, 7185-7196, Publication Date: 2018 (Link To Paper)

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NanoSurface PlatesArianna KieserApril 27, 2018Human Pluripotent Stem Cells, Cardiomyocytes
Evaluation of the Periodontal Regenerative Properties of Patterned Human Periodontal Ligament Stem Cell Sheets
Evaluation of the Periodontal Regenerative Properties of Patterned Human Periodontal Ligament Stem Cell Sheets

Joong-Hyun Kim et al. J Periodontal Implant Sci. , 47(6): 402–415, Publication Date: December 2017 (Link To Paper)

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NanoSurface PlatesArianna KieserDecember 31, 2017Human Periodontal Ligament Stem Cells
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Mantarray™
3D Engineered Tissue Contractility Analysis

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Cell Stretching Instruments

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Structural Maturation of Cardiac & Skeletal Muscle Cultures

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