3D Engineered Tissue Casting Kits

Ready-to-Cast Consumables, Assay-Ready Cells, and Validated Media for Human 3D Tissues

Kit	Compatibility	Cells Included	Key Functional Readouts	Example Applications
Skeletal Muscle Engineered Muscle Tissue	24-well 96-well	iPSC-derived myoblasts; healthy and disease lines, isogenic pairs	Twitch & tetanic force, fatigue, force-frequency	Muscle disease, atrophy, metabolism, gene therapy
Heart Engineered Heart Tissue	24-well 96-well	iPSC-derived, assay-ready cardiomyocytes	Twitch force, beat rate, contraction and relaxation kinetics	Cardiac safety and efficacy, cardiomyopathy modeling
Neuromuscular Junction Motor Neuron–Muscle Co-Culture	24-well	Blue light–sensitive iPSC-derived motor neurons + myoblasts	Optogenetic vs. electrical force, % innervation	Neurotoxin (BoNT) potency, neuromuscular disease

*Cells are for research use only. Not for use in diagnostic procedures.

 💡 Special Pricing: Available for first-time orders. Contact us for academic and bulk volume pricing.

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3D Tissue Engineering, Made Simple

Everything you need to build human 3D tissues, in one kit. Cast reproducible tissues that stay functional for weeks, and capture maturation-dependent and chronic phenotypes in real time on Mantarray™.

What's in Every Kit

**Casting Consumable**

Ready-to-use casting plate and lattice for uniform, reproducible tissue geometry.

**Assay-Ready Cells**

Cryopreserved human cells, quality controlled and ready to cast straight from the vial.

**Validated Media**

Formulations validated to support tissue compaction, maturation and function for 3 weeks in culture.

Functional Human Tissues for Weeks in Culture

Extended culture windows let maturation-dependent and disease phenotypes fully emerge across skeletal muscle, cardiac and neuromuscular junction tissues.

3D Skeletal Muscle: DMD Model

Isogenic DMD EMTs show robust deficits in twitch and tetanic force vs. WT controls. Extended culture lets disease phenotypes fully emerge, opening a wide window to test therapies.
*Smith et al., J Tissue Eng, 2022*

Engineered Heart

Stimulation training in culture yields a positive force-frequency response at day 22, a hallmark of mature myocardium.
*Curi Bio Data*

NMJ: Neurotoxin Testing

Tubocurarine rapidly blocks light-evoked force, which recovers after washout. Weeks-long NMJ function supports acute, chronic and recovery-phase neurotoxin testing.
*Fleming et al., CRTOX, 2025*

Begin Your 3D Tissue Research Today

Bring human biology into your preclinical pipeline earlier. With Curi Bio's 3D Engineered Tissue Casting Kits, you can test compounds directly on functional human muscle, cardiac and NMJ tissues before moving into costly in vivo programs.

Human-relevant answers, sooner: Assess efficacy and safety in human iPSC-derived tissues to reduce the risk of late-stage failures driven by poor animal-to-human translation.
From acute to chronic dosing: Run single-dose, repeat-dose and washout studies in the same tissues to see how function changes over days and weeks, not just hours.
Built for modern preclinical workflows: Generate functional human data that supports the move toward new approach methodologies (NAMs) and less reliance on animal models.

Request a quote today or speak to a specialist to find the right casting kit for your preclinical program.

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